ZIA CP010136-02337 (ZIA) | |||
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Title | Cancer Risk in Human Populations | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | T Silverman, Debra | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $128,222 | Project Dates | 03/01/2001 - N/A |
Fiscal Year | 2009 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Alcoholism Research (5.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) Pesticides (100.0%) |
Breast (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
This project is part of a breast cancer case-control study conducted in Shanghai, China. The original study included 1200 newly diagnosed breast cancer cases among women aged 25-64 and an equal number of frequency-matched population controls. 85% of study subjects were collected blood samples. In a pilot study, we have found that serum DDE and beta-HCH levels in Shanghai were much higher than those in U.S. population. To examine 1) the associations of breast cancer with serum levels of organochlorine residues, 2) the associations of breast cancer with CYP1A1 polymorphisms, and 3) whether there are interactions between organochlorine compounds and CYP1A1 in the development of breast cancer in Shanghai, we pull a subset of the data set to conduct a serum pesticide and polymorphism assay. |